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Similarly, melanoma-secreted exosomes contain miR-498 and miR-3187-3p which are internalized by CD8 + T cells, where miR-498 interacts with the 3’UTR of Tnf (encoding tumor necrosis factor alpha, TNF-α) mRNA to reduce TNF-α secretion by T cells and miR-3187-3p binds with 3’UTR of protein tyrosine phosphatase receptor type C (Ptprc) mRNA, impairing CD45 production and T cell receptor (TCR) signaling in CD8 + T cells [136] https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs44372-025-00089-4/MediaObjects/44372_2025_89_Fig1_HTML.png body health Size:Refill Pack of 12 Triglyceride-rich lipoprotein metabolism. Shaded molecules (purple) are... | Download Scientific Diagram

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