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The first-pass effect must be taken into account when designing dosing regimens because, if hepatic metabolism is extensive, the amount of drug that reaches the target tissue is much less than the amount (dose) that is administered orally (see Chapter 3, Pharmacokinetics) https://dermaquestclinical.co.uk/cdn/shop/files/Tube_045oz_C_Infusion_LipHydraator_38232b16-c770-4e26-878d-78520760ae7d.png?v=1725897520&width=500 FREE FROM:Lactose Size:30 pcs Histamine Intolerance: The Current State of the Art
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