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#CommunityPharmacy #DrugDrugInteraction #ClinicalPharmacy #MedicationSafety #PatientCounseling #PharmacyPractice To view or add a comment, sign in 🌟 Managing Pyrexia with Dabrafenib/Trametinib: A Pattern Interrupt 💡 🔹 Pyrexia is a common adverse effect of dabrafenib/trametinib (DT) therapy, affecting 63% of patients in COMBI-AD study 🔹 Standard management strategies are often reactive and may lead to treatment interruptions, dose reductions, or discontinuation 🔹 Colchicine, a gout drug, may be a useful adjunct in managing recurrent DT-associated pyrexia 🔹 Colchicine's mechanism involves inhibiting inflammatory pathways, reducing fever recurrence and steroid reliance 🔹 Consider colchicine in patients with recurrent pyrexia, steroid dependence, or repeated DT dose holds 🔹 Monitor for gastrointestinal toxicity and potential interactions with CYP3A4 and P-glycoprotein substrates #OncologyPharmacy #MelanomaTreatment #DabrafenibTrametinib #PyrexiaManagement #Colchicine #TargetedTherapy #AdverseEffectManagement #clinicalpharmacy To view or add a comment, sign in SKYROCKETING: Swiss drug costs hit a record high—over 9 billion francs in 2024 https://lookaside.instagram.com/seo/google_widget/crawler/?media_id=3957240640010692948 foot protectors for shoes Quantity:30 Capsules Boots UK vs Holland & Barrett: A new Balance of Power in Nutraceutical Retail The demerger of Boots from Walgreens is more than a corporate reshuffle. It reshapes the competitive landscape in