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Hyperglycemia downregulates key anti-inflammatory mediators such as indoleamine 2,3-dioxygenase (IDO), IL-10, and complement factor H (Khasawneh et al., 2024), whereas inflammatory stimulation induces excessive secretion of pro-inflammatory cytokines, including IL-6, IL-8, and IL-1β (Li et al., 2024)
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These increased amounts may serve a protective role since premature infants have poorly functioning neutrophils, limited production of Igs, and lower levels of passively acquired Igs
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