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Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis
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By reducing intracellular ROS levels, this inhibition enhances the expression of ZO-1 and E-cadherin, and suppresses the expression of p-PI3K/PI3K, p-mTOR/mTOR, fibroblast-specific proteins ferroptosis suppressor protein 1 (FSP1), and α-SMA, which are associated with fibroblast differentiation, thus alleviating fibrosis (Suryantoro et al., 2023)
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