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Not only that, the nanoparticle vaccine R848-GA@TCLs based on sulfite-modified Toll-like receptor 7/8 (TLR7/8) agonist R848, can promote the production of pro-inflammatory cytokines, activate DCs, and significantly increase the number of effector T cells, NK cells, and M1 TAMs, markedly inhibiting tumor growth and metastasis in various tumor models (218)

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As expected, both compounds provide sufficient PD effect at 100 mg daily doses (Table II)