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5 There are currently 4 major types of outcome measures used to assess DMTs in clinical trials: clinical outcomes (eg, measures for relapses and disability), biological markers (eg, magnetic resonance imaging [MRI] scans, neurofilament light chain [NFL], and cerebrospinal fluid [CSF] oligoclonal bands), composite measures that consist of some combination of clinical outcomes and biological markers, and patient-reported outcomes [PROs] that measure quality of life (see Figure 1 )
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