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Mutations that cause CGD are found in CYBB and CYBA , which encode the membrane-bound NADPH oxidase components Nox2/gp91 phox and p22 phox , and NCF1, NCF2 , and NCF4 , which encode the cytosolic regulatory factors p47 phox , p67 phox , and p40 phox , respectively (Figure 1) (O'Neill et al., 2015)
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