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Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy - PMC
However, whereas perturbations of reactions that are close to equilibrium are unlikely to have large effects on steady‐state flux (as discussed in Section II.4), this does not automatically mean that reactions that are far from equilibrium are rate‐limiting steps (Noor et al ., 2014
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For example, ligands which selectively bind to the allosteric sites and inhibit the binding of cocaine without modulating DAT uptake behavior can be utilized for the treatment of cocaine-related substance use disorder
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