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Document all adverse events using standardized scales (e.g., Common Terminology Criteria for Adverse Events) to distinguish between minor transient reactions and protocol-limiting toxicity

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TBI disturbs the balance between pro-apoptotic BAX, which forms pores in the outer mitochondrial membrane, and anti-apoptotic B cell lymphoma 2 (BCL-2), a pro-survival protein that binds to BAX (Wennersten et al., 2003