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Lactylation in cardiovascular diseases (CVDs) The involvement of lactylation in the pathogenesis of CVDs, particularly atherosclerosis and myocardial infarction, as well as in conditions such as vascular calcification, neointimal hyperplasia, pulmonary hypertension, heart failure, and radiation-induced heart damage (RIHD), is becoming increasingly elucidated

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Also, animals fed a high-fat diet have been shown to have increased OxS and dysfunctional mitochondria (136)