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[47] found that three lysines in the DNA-binding domain of p53 were mutated to arginine (K117/161/162R, namely p53 3KR ), p53 3KR can further restrict cystine uptake by inhibiting SLC7A11 gene transcription, make tumor cells more sensitive to oxidative stress-induced ferroptosis

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5.4 Design principles Several principles emerge for integrating ferroptosis modulation into reconstruction practice: First, microenvironmental assessment should guide intervention selection