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Frontiers | Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation

Selenium’s antioxidant capabilities and function in promoting the activity of antioxidant enzymes may have implications for lowering oxidative stress, even though there is little direct study on its impact on adrenal hormone imbalance-related oxidative stress (136)

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Among the few studies available, it has been shown that rats on Se-deficient diets present higher carcinogen-induced aberrant colon crypts and hypomethylated liver and colon DNA, possibly increasing tumorigenesis [13,14,15]