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Through a combination of in silico docking analysis, RT-PCR, siRNA, and clinical data mining, the study demonstrated that amitriptyline binds to TLR4, effectively inhibited TLR4- and IL-1 receptor-mediated signaling pathways in human OA chondrocytes, downregulated NLRP3 inflammasome expression, and diminished the production of IL-1β and stimulated anabolic effects within chondrocytes
3 cells
Size:Deluxe Sample
These investigations remain exclusively within Research Use Only laboratory applications
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