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However, the main factor underlying the clinical failure of chemotherapy, especially in recurrent and metastatic tumors, is the acquisition of chemoresistance
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447 Alterations in mitochondrial dynamics also induce inflammation by mislocation of mtDNA and activation of the NLRP3 or cGAS-STING pathways, which may explain the link between dysregulation of mitochondrial dynamics and some aging-related phenotypes
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