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Zhang from Peking University have shown that when the particle size of nanocrystals is reduced from 2.5 μm to 200 nm, the bioavailability can be enhanced by 3-5 fold (Wang et al., 2020)
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Belvarafenib has been tested in a phase I study including patients affected by advanced solid tumors harboring RAS or BRAF mutations, demonstrating good safety profile and antitumor activity (32)
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