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Decreased insulin signal causes decreased expression of low-density lipoprotein 2 (LRP2) Low-density lipoprotein 2 (LRP2) plays a role in the retention of insulin from the kidney
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The bypass of platinum adducts by TLS is mediated by a specific group of DNA polymerases including POLH , POLI , POLK , REV1 , as well as REV3L/POLZ and MAD2L2/REV7 , and increased expression of these genes is correlated with platinum resistance [14]
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