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Furthermore, recent findings provide evidence of alterations of the gut microbiome and some related metabolites in patients with both immunotolerant or immuno-active phase of HBV infection (Li et al., 2022)

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It is important to note that only the work of Adair (2001) evaluated oxidative status before and after NAC intervention, and the results showed no differences in the levels of glutathione peroxidase, GSH and thiobarbiturate reactive substances (TBARS), which may be related to the low prescribed dose of 50 mg/kg per day [39]