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Compounds such as baicalein, ginsenosides, natural polysaccharides (Qian et al., 2018) have shown potential in inhibiting fibroblast proliferation and differentiation and reducing ECM synthesis by modulating various signaling pathways, including STAT3/miR-21/Spry1, Smad2/CTGF, Wnt/β-Catenin, and β-Catenin, thereby mitigating tissue fibrosis progression, as summarised in Figures 2, 3, and Tables 3–6
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Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG
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