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Robinson et al., preprint, DOI: Interestingly, gravin was previously shown to play a role in β 2 -AR desensitization, sequestration, and resensitization, as agonist stimulation of the β 2 -AR increased interaction between the receptor-gravin complex and protein kinases A and C, GRK2, β -Arr, and clathrin (Bagchi et al., 2018)
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A number of neurotransmitter receptors are modulated by neurosteroids, including the γ-aminobutyric acid (GABA A ), N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, glycine, 5-hydroxytryptamine (5-HT 3 or serotonin), sigma type 1 (σ 1 ), nicotinic acetylcholine, and oxytocin receptors, and the modulation can be positive or negative depending on the steroid identity [36]
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