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Indeed, the transition state of the GTP to GDP hydrolysis is stabilised by the positively charged arginine finger, which neutralises the negative charges arising from GTP phosphoryl transfer, enhancing the catalytic ability of neurofibromin [287,288,289,290,291,292]
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Exogenous sources of ROS In addition to physiological sources, ROS/RNS can also be generated due to the exposure of biological systems to external factors
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