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Oral glutathione has generally been well tolerated in small studies Long-term safety data for oral use is still limited IV glutathione carries significantly greater safety concerns IV use for cosmetic or unapproved wellness purposes is not the same as medically supervised IV therapy If you are curious about IV-based wellness treatments, it is worth exploring options like IV hydration and vitamin drips that are administered under professional supervision, rather than pursuing unregulated IV glutathione services