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The platelet-derived growth factor-mediated pathway, which promotes the proliferation of PASMCs and an inflammatory environment, has also been identified as a therapeutic target.89 Imatinib, a tyrosine kinase inhibitor currently used to treat multiple cancers, was the first antiproliferative to have demonstrated clinical efficacy in phase 2 and 3 trials of PAH when administered orally

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Massage in circular motion for better absorption