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For instance, pH-sensitive systems release drugs in the acidic tumor microenvironment and temperature-responsive systems are activated in injured/tumor tissues where the local temperature is increased
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Finally, the statement of Marshall Urist, the BMPs concept founder, about the mechanism of the release from BMP delivery system to mesenchymal cell receptor mechanisms as obscure and under intensive investigation in academic and industrial laboratories (Urist, 1996) is true also nowadays, and it can be generally applied to any of the peptide + carrier complexes
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