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Acknowledgements The authors acknowledge support from the Canadian Institutes of Health Research (CIHR

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(2) Dual blockade of the NF-κB/AP-1 signaling axis via inhibition of IKKβ phosphorylation (IC50 = 5.8 μM) to reduce NF-κB nuclear translocation, coupled with suppression of JNK/ERK phosphorylation (EC50 = 7.2 μM) to impede c-Jun/Fos complex formation, thereby synergistically downregulating MMP-1/3/9 transcription (Liu et al., 2024)