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The STAT3 signaling pathway primarily contributes to immune suppression and is typically stimulated by cytokines such as interleukin-6 (IL-6), IL-10, and certain growth factors, including epidermal growth factor (EGF), transforming growth factor-β (TGF-β), and insulin-like growth factor (IGF) (309, 310)

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In this context, dysregulated levels of metabolites might disturb epSPC differentiation, and their restoration might favour their proliferation and differentiation, as well as the release of neurotrophic factors