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rather, it is embedded within a broader neurobiological framework that continuously integrates metabolic cues from peripheral tissues, thereby linking nutritional exposures to central regulatory mechanisms

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For example, Kennedy (2021), in a systematic review of theobromine and theophylline, stated that although the studies showed contradicting results and/or insufficient data to draw solid conclusions, it appears both drugs have the potential to enhance performance and could be considered for inclusion on the WADA banned list [36]