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The 2001 study used obese and β3-AR knockout mice: chronic treatment reduced body weight and increased lipolytic sensitivity in wild-type animals, but those effects were absent in the knockouts
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A previous study has established inhibitory effects of CD38 on cardiac hypertrophy and fibrosis through the inhibition of SIRT3 expression and activation Ca 2+ -NFAT signaling pathway, as confirmed in vitro and in vivo models [10]
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