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While CMS2 is indistinguishable from CMS4 in terms of CIN and MSS, CMS2 is differentiated from CMS4 due to the aberrant activation of WNT and MYC pathway (i.e., canonical pathway) as well as overexpression of oncogenes (e.g., EGFR , HER2 , IGF2 , IRS2 , HN4FA )
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