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Because of this, some researchers prefer a less frequent dosing schedule (e.g., 10 mg twice a week) to prevent over-saturation

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Interestingly, in GPx-1-replete cells, compared to those with GPx-1 deficiency, the presence of GPx-1 can mediate a dramatic decrease in GSH and GSH/GSSG ratios in response to acute oxidative stress (136, 229)

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