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The rate-limiting step of a thiol-Michael addition in solution is commonly believed to be the nucleophilic attack of a deprotonated thiolate on the electron deficient β -carbon of the olefin, resulting in a carbanion intermediate which reprotonates to yield the adduct (Figure 1c)

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LINKS for further reading: Remember, small changes can make a big difference in supporting respiratory wellness and investing in your health is an investment in a brighter and more fulfilling future