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Such an increase in MDA-modified proteins, anti-SOD, and anti-catalase antibodies in SLE patients induces oxidative stress with the onset of the disease ( Interestingly, these ROS indicators of oxidative damage can be considered for the development of biomarkers ( 4 Armory of immune cells dysregulating SLE 4.1 Functional influence of T cells and B cells in SLE T cells play a major role in the initiation of SLE, and uncontrollably activated B cells are produced by T-cell dysregulation, which impacts peripheral immune tolerance

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We have first replicated the treatment protocol previously carried out with FR-1, 18 injecting the peptide intrahippocampally to verify if it could produce a more potent effect in terms of changes in the extracellular matrix (Figure 5a)