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Consistent with this hypothesis, interrogation of our gene expression microarray data sets revealed increased expression of several JNK regulatory genes including the toxicity and JNK inducer TAJ ( TNFRSF19 , 8.33-fold, adjusted P -value 1.25 × 10 −18 , Supplementary Table 1), and JNK target genes including the p53-inducible proteins TP53I3 ( PIG3 , 5.02-fold, adjusted P -value 1.73 × 10 −16 ) and CDKN1A ( p21 , 4.87-fold, adjusted P -value 9.62 × 10 −15 ) in GSTP1 knockdown cells