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It involves initial permeabilization of the mitochondrial outer membrane, followed by an abrupt change in inner membrane permeabilization allowing exit of molecules less than 1500 daltons [89,90]

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1 These include the direct effect of alcohol on an individual, including alcohol withdrawal and metabolism rates, as well as non-alcohol causes, including other components found in the consumed beverages, use of other drugs (especially nicotine), personality type and family history of alcoholism