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SIRT1 is a histone deacetylase, which may regulate the transcriptional activity of BMAL1/CLOCK, forming a metabolic feedback loop again between the circadian clock system and metabolism ( The last pathway is that the circadian clock system controls cell metabolism by regulating the nutrient sensors Sirt1 and AMP-activated protease (AMPK) ( + levels ( The circadian rhythm system, CLOCK gene mechanism and metabolic pathways are intertwined by neural circuits which transmit the environmental signals to peripheral organs through hormones, chemokines and neuropeptides ( GH-IGF-1 Axis One major function of GH is to stimulate tissue growth
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