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MET activation is thus involved in brain plasticity, as suggested by the fact that HGF administration on hippocampal slices enhances the phosphorylation of the glutamatergic NMDA receptor subunit GluN1, augments the NMDA-mediated currents, and increases the amplitude of long-term potentiation (LTP) induced by elevated neuronal activity (Kato et al., 2012)

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Consistent with the role of ISCA1/ISCA2 and IBA57 in the biogenesis of [Fe 4 -S 4 ] clusters for a subset of mitochondrial proteins, a mutation affecting the stability of IBA57 was recently found in two patients with severe myopathy and encephalopathy associated with compromised activities of the lipoic acid dependent enzymes, indicating defective maturation of LIAS [36]