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Patients with a history of receiving ≥ 3 types of treatments, including but not limited to lifestyle modifications, oral medications (famotidine, loratadine, deanxit, pregabalin), acupuncture-physiotherapy, intravesical hyaluronic acid instillation, botulinum toxin intradetrusor injection, cystoscopic hydrodistension, sacral neuromodulator implantation, etc., without symptomatic improvement