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5 Role of VEGF-A during hypoxia and inflammation During hypoxia and inflammation, endothelial cells are stimulated to release HIF-1α, which, via its role as a transcription factor, upregulates genes that mediate adaptive responses to lower oxygen availability, such as those encoding erythropoietin, VEGF-A, PDGF, and smooth muscle mitogen, to compensate for ischemic and hypoxic damage (Korgaonkar et al., 2008
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