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Future research should focus on developing precise delivery systems, optimizing combination therapy strategies, conducting patient stratification and biomarker-guided approaches, as well as performing long-term safety monitoring and analysis of drug resistance mechanisms
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This mechanism of inhibiting proteasome activity may be achieved by targeting nuclear protein localization protein 4 homolog (NPL4), which is the adapter factor for the p97 (also known as VCP) segregase, involved in the conversion of proteins involved in multiple regulatory and stress response pathways (198)
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