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On the premise of maintaining the therapeutic effect of biological system, attention should be paid to reducing or reducing the toxicity in vivo and speeding up its biodegradability.In addition to the primary issue of biocompatibility, the absence of a perfect preparation method is also the key hindering the clinical application of MnO 2 NPs.Currently, there are many methods to prepare nanomaterials, which have their own advantages but also their own obvious disadvantages, such as difficult preparation methods and high cost, difficult to control the consistency of nanomaterials, potential dangers and environmental pollution (134, 135)