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Methods Eligibility criteria The PICOS strategy was defined as follows: “P” (participants) human subjects, “I” (interventions) oral LC treatment, “C” (comparisons) between supplementation and placebo, supplementation and control, or pre- and post- supplementation, “O” (outcomes) muscle variables, and “S” (study design) randomized controlled trials, non-randomized controlled trials, non-randomized non-controlled trials

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by site-directed mutagenesis in the lid domain based on computer simulation