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Ouabain, a natural compound belonging to the cardiac glycosides’ family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion
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Patients with liver cirrhosis often exhibit hypermethioninemia and have impaired methionine clearance because the activity of hepatic MAT is significantly impaired (Mato et al., 2002)
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