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“We’re particularly excited at the prospect of using patient-derived cells to 3D-print the next generation of these skin organoids,” note Hayman and Zhu, “because this would allow us to incorporate patient-specific biology into the drug discovery pipeline, and ensure that the drugs we are spending time and money to test are actually showing effectiveness in the cellular environments they will eventually be used in.” The spotlighted work was funded by the National Institutes of Health and the Cure Acceleration Network Program

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Patients with constitutional mismatch repair deficiency (CMMRD) and Legius syndrome (caused by germline SPRED1 mutation) may have overlapping clinical symptoms, underlying the need for molecular diagnosis [13]