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Oral May Be a Logical Starting Point When: your primary goal is gut-focused support you want local mucosal exposure plus systemic absorption you prefer simpler administration Injectable May Be Considered When: oral route isn’t producing results after 4–6 weeks absorption is severely compromised your clinician prefers more predictable systemic levels Step-By-Step: A Testing-Informed Gut Healing Protocol Step 1: Baseline Testing (Before Peptides) GI-MAP (often paired with zonulin when clinically appropriate) Provider-directed safety labs (CMP +/- CBC) hs-CRP trend marker Symptom baseline tracking (bloating, pain, bowel patterns, food reactions, energy, sleep) Step 2: Address Drivers First Delay peptides if testing suggests: active SIBO requiring targeted treatment parasites requiring eradication significant dysbiosis needing microbial strategy H

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Blood 139 , 936–941 (2022)