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However, evidence directly applicable to musculoskeletal clinical outcomes remains limited

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Particularly in vascular endothelial cells, hypoxia accelerates endothelial cell senescence, significantly affecting vascular dilation function ( The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis ( The Forkhead box O (FOXO) proteins are an important subclass of the Forkhead family