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[2] It is also important to meet with the prescribing doctor at regular intervals to review the medication's effectiveness, manage any adverse effects, and alter the dosage if needed

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Perhaps the closest he comes to this consideration might be his mention of nostril dilation in fearful horses, but he argues that this is the result of an association between fear and the exertions of rapid flight (Darwin, Reference Darwin1872: 130), rather than functioning to detect a source of danger