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295,296 Furthermore, targeting CCR4 and CCR8 not only reduces the recruitment of Tregs but also enables the direct elimination of effector Tregs expressing these chemokine receptors through the ADCC, representing highly promising therapeutic strategies for TI-Tregs
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Unlike the lung, the heart’s role in inflammation is closely tied to vascular integrity: activated cardiac endothelial cells secrete vascular endothelial growth factor (VEGF), disrupting the BBB and promoting cytokine entry into the brain [117]
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