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In summary, under mediation by the PGC-1α/ROS/apoptosis signaling pathway, AS-IV promotes mitochondrial biosynthesis, as well as the upregulation of mitochondrial membrane potential, in the peritoneal tissue of peritoneal fibrosis rats by activating its pharmacological target PGC-1α
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The effects of insulin are initially mediated by the binding of the hormone to the insulin receptors on the cell surface
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