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Does Glucose-6-Phosphate Dehydrogenase Deficiency Correlate with Increased Sensitivity to Cisplatin? A Case Report and a Narrative Literature Review

This has been described in human studies when concentrations of GH and IGF-1 increase in cerebrospinal fluid (CSF) posterior to the GH replacement therapy ( In animal models, homozygous deletion of IGF-1 or IGF-1R genes results in high lethality and severe CNS deficits, including reduced brain size and loss of specific neurons, highlighting the essential role of IGF-1 signaling in neurodevelopment ( 2.7 Endothelial function and vascular health HGH is directly involved in maintaining vascular health, primarily through stimulating nitric oxide (NO) production, a short-lived gas considered an essential vasodilator

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