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Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the α-ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety
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This significant cytoplasmic accumulation of HIF-1α appears to be a result of enhanced protein stabilization before its translocation to the nucleus
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